The Australian Open has claimed its first major upset as World Number 2 Novak Djokovic got knocked out of the first round.

Djokovic’s shock loss came at hands of the World’s 117-ranked player, Uzbekistan’s Denis Istomin. The match lasted 4 hours and 48 minutes in what would prove to be the biggest upset of the iconic Serbian’s career.

Istomin won the grueling encounter 7-6 (8), 5-7, 2-6, 7-6 (5), 6-4, and consigned Djokovic to his earliest Grand Slam exit since the 2008 Wimbledon. It’s also the first time Djokovic would lose to a player ranked outside the top 100 in an ATP event.

With his exit, current World Number 1 Sir Andy Murray is the odds-on favorite to win the Australian Open.

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The Australian Open is usually Djokovic’s best Grand Slam, as he’s won half of his 12 career Grand Slams in Melbourne.

“He deserved to win. No doubt, he was a better player in the clutch moments,” said liest grDjokovic after the game.

“Many things came together for him today and he’s a well-deserved winner. There’s not much I could do.”